CLINICAL CHEMISTRY

• cellulose acetate membranes
• agarose gels
• manual systems (power supplies, migration chambers, applicators) with densitometers and scanner programs
• fully automatic systems (bench top) in different sizes.

ANALYTICAL CHEMISTRY

All spectrophotometers are operating through a common platform (Spectra Manager^®).
Optional for all instruments: CFR 21/part 11-compliance.


• FT/IR:
  for routine & advanced research, range from 15.000-10 cm^-1,
  different detectors (DLATGS standard, various MCT detectors, etc.), all possible data handling programs incl. library build up and search (Know-It-All JASCO ed.) via international data pools. Validations, special software packages for secondary structure estimation of proteins, etc. available.
  Optional: microscopes, Raman accessory.

• Raman:
  single and triple monochromator instruments, standard and multiconfiguration instruments, CCD.

• UV/VIS/NIR:
  for routine and research (up to double-monochromator units and ranges up to 3200 nm); 8 or more routine measurement programs as standard; control via PC; many optional other programs available.
  Extensive accessories: various cell holders for micro-, long path-cuvettes, HPLC, film holder, cell changers, sippers, reflectance units, autosampler.
  Special software packages: different color measurements, multicomponent analysis, DNA-melting curves, etc.
  
  
Special models for biochemistry and "high-end" units.

• Dissolution Tester:
  8 vessels, paddle and/or optionally basket method, integrated water bath; measurements according to USP, EP,JP and under full CFR-21/11 compliance.

• FLUORIMETRY:
  Routine up to high-end research instruments, including phosphorescence and life-time measurements.
  Extensive accessories:
  Sipper, various sample holders, epifluorescence, microtiter plates, as well as special programs, like
  intracellular Ca²⁺- measurements.

• POLARIMETRY:
  Digital polarimeters with fast response speed, minimum angle 0,0002°, Na-lamp and other lamps for other wavelengths available; HPLC-monochromator as option.
  Standard methods: optical rotation, specific rotation, concentration, sugar scale, Brix purity, optical purity.

• SPECTROPOLARIMETRY (ORD/CD):
  Research-grade chiroptical spectrometer for circular dichroism (CD) and optical rotary dispersion (ORD).
  Options for linear CD, stopped flow, titration, fluorescence, different magnets, different cuvette holders and changers, etc.
  Additional programs for estimation of secondary structure of proteins, temperature control, etc.

• STOPPED FLOW/FAST KINETICS:
  As accessory to all CD/ORD spectrometers or fluorescence photometers.
  2-4 syringes, individually driven with variable flow rates and mixing ratio, Peltier thermostatting.
  Optional: titration unit, anisotropy measurements (fluorescence), freeze quench, etc.

• Pumps:
  for capillary, micro bore, analytical, UHPLC and (semi)preparative applications in modular design for high-pressure gradients (up to 3 pumps) and/or low-pressure quarternary gradients.

• Autosamplers:
  ambient or Peltier thermostatted for 60-180 normal vials (2 ml) and/or 96/2x96 microvials and/or 1/2x96 or 1x 384 microtiterplates and/or conical plastic vials, respectively;
  including precolumn derivatization and sample dilution, up to 6 different sample injection modes, electromechanically driven valves (no compressed air necessary).

• Detectors:

• UV/VIS: 190-600/700 nm, highest sensitivity, wavelength switching, spectral scanning; optional cells (micro, preparative, high pressure).



• Diode Array:
  "big" DAD: 190-900 nm, highest sensitivity, all data transformations and 3D-presentation possible;
  2 "small" DADs: as multi-wavelength detectors with up to 4 freely selectable wavelengths, range 200-400/600 nm.



• Fluorescence:
  programmable double monochromator (Em/Ex) with highest sensitivity. Range 200-700/opt. 900 nm (Em/Ex), incl. wavelength switching and spectral scan in-the-flow. 2 wavelengths settings/measurements
  possible.
  Optional: rectangular cell holder, various flow cells incl. micro.

• Refractive Index:
  n= 1.00-1.75, highest sensitivity (2.10^-9 RIU), built-in Peltier-thermostatting, programmable filling of reference cell.



• Chiral:
  Range 350-900 nm, for optically active substances, angular range +/- 500 mº.



• CD:
  spectropolarimetric detector with 2 simultaneous signal outputs (CD + UV), highest sensitivity, range 200-460 nm, noise level
  5.10^-5 deg/291 nm.

• Evaporative Light Scattering:
  For HPLC or SFC.
  Different models ranging from routine-type to high performance level, also as 4-channel detector for LC/MS;
  Internal and external control feasible; gradient elution possibility as a true universal detector for most substances.

• Column ovens
  Different models: with Al block or air circulation; for analytical or preparative columns and SFC/SFE; post-column derivatization.
  
  
• Fraction collectors
  direct hooking and central control of some instruments commonly found in the market.

• Latest state-of-the-art PC-based program (64 bit) for HPLC systems for 1-4 detectors, autosamplers, other peripheral units etc., including central control of all modules. All possible integration programs, GLP-reporting under CFR 21/11-compliance, audit trails, etc.
  Graphical HPLC configuration setting, real time monitoring, free report editing.

• based on the HPLC modules (pumps, detectors, autosamplers, column ovens) of the respective HPLC series for analytical flow rates to preparative units (up to 150 ml/min liquid CO₂), patented back pressure valve, fraction collectors.

• Universal instrument for physiological fluids and hydrolysates using post-column-derivatization (ninhydrine), unit based on HPLC technique modules with Peltier-thermostatted column oven and derivatization reactor, 2 maintenance free microphotometers, thermostatted autosampler (216 vials or 4x96 samples/microtiter plates), including complete integration software and central control.

• HPLC columns of all dimensions (capillary, micro bore, conventional, semi-preparative, preparative) with particle sizes from 1,5 to 10 µm.
  Wide range on stationary phases of practically all origins.
  Guard columns and holders, tool-free couplings, also PEEK-columns.

• Vials for crimp, screw, open, head space; micro-vials, conical vials etc. for nearly ALL types of autosamplers of ALL manufacturers
  (Nearly) all types of septa, caps and crimping tools.
  Microtiter plate formats (glass vials) for combinatorial chemistry, directly inserting in suitable autosampler.

• Freely configurable actuators for multiposition switching valves with programming via PC, integrated in nearly all data systems of the various manufacturers. Suitable for HPLC, HPLC/MS, microdialysis, sample clean-up, on-line analytics.
  Special customized solutions available.